[Alex doesn't ask the question, because let's be real, she's someone who wouldn't want to be asked so she gets it and respects it. Instead she's going to offer an alternative reason why Skye might be awake right now:]

Well, let's be honest here, that's the sort of thing that keeps a person up at night. It's a bit like a splinter in your brain that way. Everything inside of you just wants to find the person and give them a shake and just be like "how HOW DO YOU NOT FIX THIS!"